Exposure to chemicals and systemic sclerosis.
نویسندگان
چکیده
منابع مشابه
Systemic Responses to Exposure to Chemicals and Their Responses as Indicators
Along with physico-chemical properties and the potential to elicit biological activity, the three routes of exposure (inhalation, contact, and ingestion) and the corresponding three portals of entry (the respiratory system, the skin, and the digestive system) determine to a large extent the fate and disposition of xenobiotics in the body (Hayes, 1984). Whatever the port of entry or the main tar...
متن کاملStrategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies.
Strategies were developed for the estimation of systemically available daily doses of chemicals, diurnal variations in blood levels, and rough elimination rates in subchronic feeding/drinking water studies, utilizing a minimal number of blood samples. Systemic bioavailability of chemicals was determined by calculating area under the plasma concentration curve over 24 h (AUC-24 h) using complete...
متن کاملAssessing the Systemic Toxicity in Rabbits after Sub Acute Exposure to Ocular Irritant Chemicals
Eye is a highly vascularised organ. There are chances that a foreign substance can enter the systemic circulation through the eye and cause oxidative stress and evoke immune response. Here the eyes of rabbits were exposed, for a period of 7 days, to 5 known ocular irritants: Cetyl pyridinium chloride (CPC), sodium salicylate (SS), imidazole (IMI), acetaminophen (ACT) and nicotinamide (NIC). The...
متن کاملStatistical analysis of clinical and laboratory characteristics of systemic sclerosis
Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and excessive collagen deposition in the skin and internal organs. Based on the skin damage we divide the patients into two groups: limited and diffuse SSc. In restricted type, the thickness of the skin is limited in the face and distal parts of the elbows and knees, with less involveme...
متن کاملAssociation between atherosclerosis and parenchymal lung involvement in systemic sclerosis
Background: Systemic sclerosis is an autoimmune disease affecting connective tissues, (including epidermal, subepidermal, microvasculature, etc.), leading to various extent of end-organ damage. The leading cause of mortality among these patients is lung involvement. The cardiovascular events happen more frequently in patients suffering systemic scleroderma, comparing to healthy population. This...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1995
ISSN: 0003-4967
DOI: 10.1136/ard.54.6.529-a